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KizzyPhD's profile
KizzyPhD
KizzyPhD
KizzyPhD
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KizzyPhDVerified account

@KizzyPhD

Virology. Vaccinology. Vagina-ology. Vino-ology. @HarvardChanSPH @CoreIDxKizzyPhD --- My tweets are my own. My science is the world’s.

Boston, MA
Joined January 2020

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    1. KizzyPhD‏Verified account @KizzyPhD 21 Dec 2020

      What is happening, often times, is selective pressure. As the virus transmits it learns how to be better at transmitting. This is why you hear “circulating faster than last variant”...

      10 replies 169 retweets 1,092 likes
      Show this thread
    2. KizzyPhD‏Verified account @KizzyPhD 21 Dec 2020

      But, don’t get in a panic over it. There will take a large amount of genetic diversity to completely make the current vaccines useless... And, here is why:

      16 replies 292 retweets 1,354 likes
      Show this thread
    3. KizzyPhD‏Verified account @KizzyPhD 21 Dec 2020

      Unlike monoclonal antibody therapies, vaccines (especially those using the whole spike protein) make polyclonal antibody responses. This means that the antibodies your vaccinated body will make will be able to bind the coronavirus spike in multiple places... not just one.

      10 replies 394 retweets 1,835 likes
      Show this thread
    4. KizzyPhD‏Verified account @KizzyPhD 21 Dec 2020

      KizzyPhD Retweeted KizzyPhD

      Remember in April when media had y’all scared over a mutation...https://twitter.com/KizzyPhD/status/1249979423987810304 …

      KizzyPhD added,

      KizzyPhDVerified account @KizzyPhD
      Taking into account this, based on previous knowledge obtained from our MERS work, we opted to target the whole spike protein and cloud that baby with antibodies from every possible angle (added to mRNA-elicited T cell responses). Here is a simulation... https://twitter.com/mgordonjoyce/status/1239609669565452289?s=21 … https://twitter.com/JulianSapp/status/1249976316989804545 …
      Show this thread
      5 replies 131 retweets 869 likes
      Show this thread
    5. KizzyPhD‏Verified account @KizzyPhD 21 Dec 2020

      Then here came the D614G mutation that had reviewers on our neck... and then boom... in the mouse paper we added results showing “mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614) and D614G mutant SARS-CoV-2” https://www.nature.com/articles/s41586-020-2622-0 …pic.twitter.com/lXML1bAbqu

      Nature Portfolio
      12 replies 128 retweets 899 likes
      Show this thread
    6. KizzyPhD‏Verified account @KizzyPhD 21 Dec 2020

      In all, please don’t be alarmed any more than you have been through this pandemic. The precautionary measures (ie. no travel) in the UK are in line with sensible measures following a regional virus spike.

      62 replies 320 retweets 2,247 likes
      Show this thread
    7. KizzyPhD‏Verified account @KizzyPhD 8 Jan 2021

      KizzyPhD Retweeted Atul Gupta, MD

      Very reassuring data from @TheMenacheryLab et. al. on the Pfizer vaccine eliciting neutralizing antibodies to N501Y mutant SARS-CoV-2!https://twitter.com/AtulGupta_MD/status/1347391689376157696?s=20 …

      KizzyPhD added,

      Atul Gupta, MD @AtulGupta_MD
      Very reassuring. Pfizer study reports the existing mRNA vaccine remains effective against both the new UK and South African #COVID19 variants as well as 14 other mutations. #SpikeProtein #N501Ymutation https://www.reuters.com/article/us-health-coronavirus-pfizer-vaccine/pfizer-biontech-vaccine-appears-effective-against-mutation-in-new-coronavirus-variants-study-idUSKBN29D0DX …
      6 replies 128 retweets 483 likes
      Show this thread
    8. KizzyPhD‏Verified account @KizzyPhD 19 Jan 2021

      Read the Full Statement of the @WHO's "Emergency Committee on COVID-19 Advises on Variants, Vaccines" here >>>https://www.who.int/news/item/15-01-2021-statement-on-the-sixth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic …

      4 replies 48 retweets 221 likes
      Show this thread
    9. KizzyPhD‏Verified account @KizzyPhD 20 Jan 2021

      "... investigated SARS-CoV-2-S pseudoviruses bearing (...) B.1.1.7 lineage spike protein with sera of 16 participants in (...) the (@pfizer) mRNA-based COVID-19 vaccine. The immune sera had equivalent neutralizing titers to both variants." https://www.biorxiv.org/content/10.1101/2021.01.18.426984v1.full.pdf …

      11 replies 21 retweets 203 likes
      Show this thread
    10. KizzyPhD‏Verified account @KizzyPhD 20 Jan 2021

      I’m just gonna post my boss here saying what I been done said. Maybe y’all will believe him. https://twitter.com/BarneyGrahamMD/status/1351918598667657216 …pic.twitter.com/Is09l2G5VK

      4 replies 48 retweets 324 likes
      Show this thread
      KizzyPhD‏Verified account @KizzyPhD 25 Jan 2021

      KizzyPhD Retweeted Moderna

      The neutralization teams have a message: "Moderna COVID-19 Vaccine Retains Neutralizing Activity Against Emerging Variants First Identified in the U.K. and the Republic of South Africa" Sorry to those who I've been ignoring yin this regard for weeks lolhttps://twitter.com/moderna_tx/status/1353698953108353024?s=20 …

      KizzyPhD added,

      ModernaVerified account @moderna_tx
      We just announced that the Moderna COVID-19 Vaccine retains neutralizing activity against emerging variants first identified in the U.K. and the Republic of South Africa. Read more: https://buff.ly/39i2cOp  pic.twitter.com/nCGl3hfhlU
      5:57 AM - 25 Jan 2021
      • 649 Retweets
      • 1,893 Likes
      • BLM and wear a fucking mask please Manuela Brinkmann 🌳 Captain Cliff word girl ⚖ Young, Boosted, and Black. Denise Dr Angela May O'Connor Diane Stewart 𝕬𝖒𝖆𝖈𝖎𝖙𝖆❦
      52 replies 649 retweets 1,893 likes
        1. New conversation
        2. KizzyPhD‏Verified account @KizzyPhD 25 Jan 2021

          The pre-print is now live: mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variantshttps://www.biorxiv.org/content/10.1101/2021.01.25.427948v1 …

          15 replies 231 retweets 770 likes
          Show this thread
        3. KizzyPhD‏Verified account @KizzyPhD 25 Jan 2021

          https://twitter.com/rmc031/status/1353837207405146114 …pic.twitter.com/QHC16x5wo4

          9 replies 17 retweets 219 likes
          Show this thread
        4. KizzyPhD‏Verified account @KizzyPhD 26 Jan 2021

          Live view of me reading yet another well-executed “tweetorial” by @florian_krammer. https://twitter.com/florian_krammer/status/1353900984209182720 …pic.twitter.com/2KNuJUHeEn

          2 replies 8 retweets 154 likes
          Show this thread
        5. KizzyPhD‏Verified account @KizzyPhD 17 Feb 2021

          Both Pfizer's and Moderna's mRNA vaccines' ability to elicit neutralizing antibodies against global variants were just published in @nejm ... https://www.nejm.org/doi/full/10.1056/NEJMc2102179 … https://www.nejm.org/doi/full/10.1056/NEJMc2036242 …pic.twitter.com/hFR1BZtE0i

          17 replies 105 retweets 472 likes
          Show this thread
        6. KizzyPhD‏Verified account @KizzyPhD 23 May 2021

          KizzyPhD Retweeted Florian Krammer

          “I got 99 problems, but a variant ain’t 1.”https://twitter.com/florian_krammer/status/1396411005312319492?s=21 …

          KizzyPhD added,

          Florian KrammerVerified account @florian_krammer
          Vaccine effectiveness of BNT162b2 against B.1.617.2 = 88% Vaccine effectiveness of AZ against B.1.617.2 = 60% https://khub.net/documents/135939561/430986542/Effectiveness+of+COVID-19+vaccines+against+the+B.1.617.2+variant.pdf/204c11a4-e02e-11f2-db19-b3664107ac42 …
          4 replies 35 retweets 380 likes
          Show this thread
        7. KizzyPhD‏Verified account @KizzyPhD 26 Nov 2021

          Live view of my phone & email re: the new variant trying to disturb my peace.pic.twitter.com/VE3IlK7W1h

          2 replies 7 retweets 133 likes
          Show this thread
        8. KizzyPhD‏Verified account @KizzyPhD 26 Nov 2021

          Live view of me doing exactly what I planned to do today: sitting at my Ma-Ma’s kitchen table, planning my wedding, praying the world heals, while drinking wine & ignoring my email.pic.twitter.com/63WTopaT4C

          12 replies 12 retweets 538 likes
          Show this thread
        9. KizzyPhD‏Verified account @KizzyPhD 27 Nov 2021

          Omicron synopsis in my email: 1. Everyone’s on top of it. 2. Right now, no one knows much re: transmission, vaccine efficacy, etc. 3. Yes, we should repurpose ongoing experiments. 4. (jokes about my tweet) 5. Darn, I missed an essay due date. 6. Insert companies’ action plan

          5 replies 31 retweets 201 likes
          Show this thread
        10. KizzyPhD‏Verified account @KizzyPhD 27 Nov 2021

          6. Repeat number 2. 7. Repeat number 1. Nowwwww … *swoops in as if I didn’t ignore my email yesterday* 8. Designs number 3.

          2 replies 9 retweets 128 likes
          Show this thread
        11. End of conversation
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        2. KizzyPhD‏Verified account @KizzyPhD 25 Jan 2021
          Replying to @fioremjm

          I co-wrote the pre-print. lol

          11 replies 29 retweets 489 likes
        3. Show replies

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