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KirkegaardEmil's profile
Emil O W Kirkegaard
Emil O W Kirkegaard
Emil O W Kirkegaard
@KirkegaardEmil

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Emil O W Kirkegaard

@KirkegaardEmil

#psychology #genomics #hbd #rstats #statistics #genomics #transhumanism #dataviz #openscience #psychometrics @OpenPsychJour

Denmark
emilkirkegaard.dk
Joined January 2012

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    1. Emil O W Kirkegaard‏ @KirkegaardEmil 23 Mar 2018
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      Excellent target for selection. Unfortunately, no info about polygenic score validity. https://www.biorxiv.org/content/early/2018/03/23/287987 …pic.twitter.com/uPlkjVoLrq

      1 reply 0 retweets 7 likes
    2. J.D. Haltigan‏ @JDHaltigan 23 Mar 2018
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      Replying to @KirkegaardEmil

      Wouldn’t this itself be provisional evidence of validity pending rep?

      1 reply 0 retweets 0 likes
    3. Emil O W Kirkegaard‏ @KirkegaardEmil 23 Mar 2018
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      Replying to @JDHaltigan

      The p factor has been found many times using many datasets. Indeed, associations between psychiatric diagnosis have been known for decades, but it was only recently researchers started adopting a factor analytic perspective. Too much box thinking of clinical psychs/shrinks.

      1 reply 0 retweets 0 likes
    4. J.D. Haltigan‏ @JDHaltigan 23 Mar 2018
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      Replying to @KirkegaardEmil

      Right but there are a host of factor analytic studies now on P. If polygenic score shows unique associations with P is this not evidence for its validity?

      1 reply 0 retweets 0 likes
    5. J.D. Haltigan‏ @JDHaltigan 23 Mar 2018
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      Replying to @JDHaltigan @KirkegaardEmil

      Polygenic score validity that is....

      1 reply 0 retweets 0 likes
    6. Emil O W Kirkegaard‏ @KirkegaardEmil 23 Mar 2018
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      Replying to @JDHaltigan

      The question makes no sense to me.

      1 reply 0 retweets 0 likes
    7. J.D. Haltigan‏ @JDHaltigan 23 Mar 2018
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      Replying to @KirkegaardEmil

      You say unfortunately no evidence of polygenic score validity above, yet is not this paper some evidence of just that?—it’s validity?

      1 reply 0 retweets 0 likes
    8. Emil O W Kirkegaard‏ @KirkegaardEmil 23 Mar 2018
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      Replying to @JDHaltigan

      I meant the correlation effect size, not existence of validity -- already know that. I'm interested in prediction, so I want to know the correlation we can predict out of sample.

      1 reply 0 retweets 0 likes
    9. J.D. Haltigan‏ @JDHaltigan 23 Mar 2018
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      Replying to @KirkegaardEmil

      So basically you’re looking for some sort of meta-analytic effect as to the predictve significance of the polygenic score?

      1 reply 0 retweets 0 likes
      Emil O W Kirkegaard‏ @KirkegaardEmil 23 Mar 2018
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      Replying to @JDHaltigan

      Not meta-analytic. Just a regular out of sample validation.

      10:06 PM - 23 Mar 2018
      1 reply 0 retweets 0 likes
        1. J.D. Haltigan‏ @JDHaltigan 23 Mar 2018
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          Replying to @KirkegaardEmil

          There’s some other similar work out there on common polygenic overlap in ASD/SSD...could bootstrap or Monte Carlo for rough estimate that will likely be close I’d imagine

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