Excellent target for selection. Unfortunately, no info about polygenic score validity. https://www.biorxiv.org/content/early/2018/03/23/287987 …pic.twitter.com/uPlkjVoLrq
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Wouldn’t this itself be provisional evidence of validity pending rep?
The p factor has been found many times using many datasets. Indeed, associations between psychiatric diagnosis have been known for decades, but it was only recently researchers started adopting a factor analytic perspective. Too much box thinking of clinical psychs/shrinks.
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Right but there are a host of factor analytic studies now on P. If polygenic score shows unique associations with P is this not evidence for its validity?
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Polygenic score validity that is....
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The question makes no sense to me.
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You say unfortunately no evidence of polygenic score validity above, yet is not this paper some evidence of just that?—it’s validity?
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I meant the correlation effect size, not existence of validity -- already know that. I'm interested in prediction, so I want to know the correlation we can predict out of sample.
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So basically you’re looking for some sort of meta-analytic effect as to the predictve significance of the polygenic score?
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Not meta-analytic. Just a regular out of sample validation.
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There’s some other similar work out there on common polygenic overlap in ASD/SSD...could bootstrap or Monte Carlo for rough estimate that will likely be close I’d imagine
End of conversation
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