if there's any place we'd see IQ genes with large positive effects wouldn't looking at exceptionally bright kids of average families be a good place to look? obviously probably just high 'dose' of 'good' genes but possible @KirkegaardEmil @gwern
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High-IQ's already been checked https://www.nature.com/articles/mp2015108 … https://www.nature.com/articles/mp2017121 … and Defries-Fulker (similar to that sibling idea) also largely rules out big rare beneficial variants being important to population variance.
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These empirical results only rule out large beneficial effects for measured variants I think. It's possible that currently poorly measured CNVs have large effects á la claims for DUF1220 https://en.wikipedia.org/wiki/DUF1220
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something I've sent to gwern already but you might not have seen: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729280/ … "We find that the number of repeats in HTT, below disease threshold, confers advantageous changes in brain structure and general intelligence (IQ):"
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Actually, this is a fail study. It's the usual exploratory subgroup analysis with pseudo sex interaction.pic.twitter.com/QFrg2ns9b2
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