if there's any place we'd see IQ genes with large positive effects wouldn't looking at exceptionally bright kids of average families be a good place to look? obviously probably just high 'dose' of 'good' genes but possible @KirkegaardEmil @gwern
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High-IQ's already been checked https://www.nature.com/articles/mp2015108 … https://www.nature.com/articles/mp2017121 … and Defries-Fulker (similar to that sibling idea) also largely rules out big rare beneficial variants being important to population variance.
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These empirical results only rule out large beneficial effects for measured variants I think. It's possible that currently poorly measured CNVs have large effects á la claims for DUF1220 https://en.wikipedia.org/wiki/DUF1220
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something I've sent to gwern already but you might not have seen: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729280/ … "We find that the number of repeats in HTT, below disease threshold, confers advantageous changes in brain structure and general intelligence (IQ):"
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Interesting. Does not fit with Jewish IQ selection from my quick googling. However, we should be able to calculate DUF1220 rates by population using public WGS datasets. If they align with group IQs, would be interesting evidence.
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