if there's any place we'd see IQ genes with large positive effects wouldn't looking at exceptionally bright kids of average families be a good place to look? obviously probably just high 'dose' of 'good' genes but possible @KirkegaardEmil @gwern
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High-IQ's already been checked https://www.nature.com/articles/mp2015108 … https://www.nature.com/articles/mp2017121 … and Defries-Fulker (similar to that sibling idea) also largely rules out big rare beneficial variants being important to population variance.
These empirical results only rule out large beneficial effects for measured variants I think. It's possible that currently poorly measured CNVs have large effects á la claims for DUF1220 https://en.wikipedia.org/wiki/DUF1220
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