This story is fantastic. Read it with my hand at my chin the whole time.https://twitter.com/mikesmariani/status/928327804546048000 …
These empirical results only rule out large beneficial effects for measured variants I think. It's possible that currently poorly measured CNVs have large effects á la claims for DUF1220 https://en.wikipedia.org/wiki/DUF1220
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something I've sent to gwern already but you might not have seen: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729280/ … "We find that the number of repeats in HTT, below disease threshold, confers advantageous changes in brain structure and general intelligence (IQ):"
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Interesting. Does not fit with Jewish IQ selection from my quick googling. However, we should be able to calculate DUF1220 rates by population using public WGS datasets. If they align with group IQs, would be interesting evidence.
End of conversation
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