Maybe this one will go down into history as yet another Euro-centrism in research that misled people! Altho to be fair, researchers
Seems unwise to care too much about Pifferian results until better GWASs are done. http://www.cell.com/ajhg/fulltext/S0002-9297(17)30107-6 …pic.twitter.com/LJScV2hLjN
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deliberately avoided non-Europeans in samples to avoid population effects. Now seems this was a bad idea, better to adjust than avoid.
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speaking of adjusting, did you see that 23andme working paper on doing just that with PGSs? https://permalinks.23andme.com/pdf/23_17-GeneticWeight_Feb2017.pdf …
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No! Thanks!
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I also reanalyzed the data and found the results to be heavily confounded by population structure (genetic autocorrelation). Did not publish
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because didn't have time, but I guess I should do that. Does someone want to write up the paper for bioarxiv? Don't bother with journal.
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