how do you discriminate from self-medication? see for ex. with tobacco here http://www.ncbi.nlm.nih.gov/pubmed/27164557?dopt=Abstract …
Maybe some of the schizo variations are actually genes that make you smoke cannabis which then causes schizo. @AmirSariaslan
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Draw the path model, and find a way to hold the offending path constant. :)
@SilverVVulpes@AmirSariaslan -
So, want to hold behav. path constant. One method: see if gen. score predicts schizo among never smokers.
@SilverVVulpes@AmirSariaslanpic.twitter.com/HmCnDJkwNC
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Alternative method: regress schizo on gen. score and cannabis use. See if can. use has incremental validity.
@SilverVVulpes@AmirSariaslan -
First method is better because current gen. scores do not measure gen. risk perfectly.
@SilverVVulpes@AmirSariaslan http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152719 … - 1 more reply
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Also possible.
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Even many behavioral geneticists tend jump to intrinsic genetic causation interpretation. Reverse sociologist fallacy!
@AmirSariaslan -
From Sesardic's great book. :)
@AmirSariaslanpic.twitter.com/WSsrZOaLPL
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Suspect pattern for many drugs is short term relief of symptoms but long term increase in underlying cause.
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Sure, we need larger samples and more detailed phenotypic data to learn more about their aetiologies.
@KirkegaardEmil
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