Haplotypes of common SNPs can explain missing heritability of complex diseases. Seems to imply local epistasis.http://biorxiv.org/content/early/2015/07/12/022418 …
If we assume epistasis is mostly local, this dramatically shrinks the number of GxG interactions to test in GWAS LASSO.
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But the high LD related correlations imply large standard errors which further implies we still need v. large samples. Sigh.
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