Our new preprint! Using adoptees in the UKB, we estimated GE interplay for educational attainment. Results suggest that half the power of polygenic scores comes from gene-environment correlation i.e. predicting the environment provided by relatives. Thread:https://twitter.com/biorxivpreprint/status/1152036144302837760 …
-
Show this thread
-
1/ Rationale: when children are adopted by non-relatives, their rearing environment is less correlated with their genotype.
2 replies 4 retweets 15 likesShow this thread -
2/ Polygenic scores are 2x as predictive of years of education in non-adopted individuals compared to adoptees: R2=0.074 vs 0.037. The R2 in adoptees approximates the direct genetic effect; the difference between the two measures gene-environment correlation.pic.twitter.com/Ei2nNHH8UC
3 replies 6 retweets 20 likesShow this thread -
3/ Individuals in the lowest decile of education polygenic score attain significantly more education if they are adopted. This could be an environmental effect of educationally supportive adoptive parents.pic.twitter.com/H4HdHvXwxE
1 reply 6 retweets 31 likesShow this thread -
4/ Thanks to my great supervisors and colleagues!
@psychgenomics@thaliaeley@Tom_A_McAdams @RobertPlomin@HunjanAvina@Joni_Coleman@yaszadeh. Comments welcome.5 replies 2 retweets 16 likesShow this thread
Very nice study. I question the use of R2 instead of the r metric. R2 is a nonlinear effect size metric and the ratio is less stark using the r.
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.