Polygenetic scores are likely not effective enough for IVF embryo selection to produce big enhancements: https://www.biorxiv.org/content/10.1101/626846v1 … Paper discounts iterated embryo selection as too futuristic but sqrt(log(N)) is tough to beat: it might be data not tech that is limiting factor.
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"Given currently available polygenic predictors" "𝑟2_ps=4.3%" ^ There's the problem. *Current* polygenic scores are shit. Someone more knowledgeable like
@KirkegaardEmil feel free to correct me. What the prospects for improving r2_ps is beyond my understanding...
Current IQ prediction is about 10%, not 4.3%. Also, there are some private PGSs that are beyond 10%. Anyone can fit the LASSO to UKBB to get a better predictor. But really, just need the academics to stop fucking around and apply the summary stats LASSO already.
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And no one is using the best and largest dataset around for IQ. https://www.research.va.gov/mvp/
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