It's a nice idea. The prediction here is that GWAS on old people fertility will not be that highly correlated with GWAS on younger people. Unfortunately, we'll have to wait some time for completed fertility before we can properly test it.https://twitter.com/RAVerBruggen/status/1138087929442684928 …
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Reference populations have to be updated in production animal genomics for just these such reasons
I think the primary reason they need to keep updating them is that the effective population size is small, and they rely upon the high LD to make variants associated for predictive purposes. The animal SNP arrays usually have much fewer markers than human ones (like 100k).
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True, but primarily for smaller/boutique pops, not for large ones that have much 'older' reference grps. eg Holstein dairy cattle. Moreover, changes to selection pressures since eg health, longevity and fertility traits have been incorporated into selection indexes in last ~15yrs
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