So his action spurred more research, and now we know that variant is associated with a fairly trivial extra risk. This is how trial and error looks like, and we should do MORE of it not less.https://twitter.com/EricTopol/status/1135563556777103362 …
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Downplaying the risk of trial and error potentially polluting the human gene pool irreversibly with serious genetic diseases created accidentally through gene editing is a markedly weak position to take.
>irreversibly Changing a few people to get homozyg. of some variant is not a irreversible change. Obviously, one could easily undo it next generation with the same technology.
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You're assuming that the deleterious effect would necessarily be discovered in the first generation. How long was something like Tay-Sachs percolating in the genomes of Jewish populations before it was discovered to be a serious problem?
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Also, every time you do it you're potentially introducing off-target mutations which are themselves deleterious. So it's not as easy a problem to solve as you suggest. The more you do it the more you compound the potential for negative unintended consequences.
End of conversation
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