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While this is not really what p-hacking means, Turkheimer does have a point that most of these GWASs going "we've got 5 hits for trait T" are useless. What happens is predictive validity, and when you have many hits, functional analysis. We have these now http://www.geneticshumanagency.org/gha/p-hacking-in-gwas/ …pic.twitter.com/SocKUhOk0w
My most positive take is that scientists knew all along these "we've now got 7 SNPs for trait T" were useless, but they propped them up to give funders something to see until larger samples could be gathered and actually useful results. They were rationally biting their time.
But my pessimist take is that probably Turkheimer is right. These scientists were pretty delusional about the utility of these early GWASs. Animal researchers didn't give a fuck about significant hits or functional analysis, they just wanted validity, and they did much better.
See, @ent3c, we can agree on something once in a while. ;)
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