@dl1dl1 you guys should implement this ASAP! :)
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New lasso results out for height, also in UKBB. About the same results as team Steve Hsu, but more fancy method. Polygenic score explains 42.8% variance in height, or r = .654. Betas public! https://www.nature.com/articles/s41467-019-08535-0 …pic.twitter.com/u0UErtEjeG
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Thanks. Twitter will use this to make your timeline better. UndoUndo
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It's quite impressive the level of accuracy you can get with linear models ("additive genetic" in genomics language) and common SNPs. I know Hsu et al have reached this level of accuracy earlier. But just generally it's quite impressive.
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Linear not the same as additive, silly bird. You can have nonlinear additive models (all loci independent but effect is not linear effect of the number of minor alleles).
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When are additive effects not modeled as linear models?
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Eg splines
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Example paper?
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