One method to attack the population stratification issue in GWASs is to use sibling design. Siblings do not differ much in ancestry, but differ a lot in polygenic scores, thus allowing effective, natural control. Somehow this study only has 1 citation??! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275846/ …pic.twitter.com/DaXSjUFyM7
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