We're hugely grateful to 23andMe for examining our associated variants in their 1.5M cohort. Hopefully, the genome-wide data for this cohort will be available in the future, but sadly it wasn't available for this research. Hope the next study of depression is less meh for you.
#GWAS for depression in 800k individuals with a replication in 1.5M individuals. Why are they not combined??? Anyway, nothing much found of interest, PGS validity about r = 0.10 (r^2 = 1%).
Pretty meh, so waiting for the next one.
https://www.biorxiv.org/content/early/2018/10/09/433367 …
#genomicspic.twitter.com/VWKR0HatiI
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Any particular reason you didn't combine the summary stats from GWASs to one big result and get the validity of that PGS (was done in previous studies using 23andme data for replication)? Or combined genetically related traits (e.g. SWB)?
End of conversation
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