Personally I find it extremely effective, overly so. It always causes me to become intensely sleepy within about 20 minutes at doses of ~1mg, but I inevitably oversleep by a couple hours and am more tired the following morning.
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At 0.5mg it is a bit less intensely soporific, though with less of an overshoot. Using an entire 3mg lozenge a few times a long time ago before doing more research generally caused severe oversleeping and tiredness much of the following day.
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Then again, GABA supplements always work well as occasional anxiolytics for me as well, so perhaps BBB permeability is higher for me than average. Unclear. Entirely speculative.
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I don't think it is a placebo. The effects are unmistakable in both cases and I have sometimes forgotten what I did to feel that way before later remembering again, which suggests that effects are apparent even without a recalled cause.
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Also what on Earth does _eating_ melatonin prove about dosing safety? It's supposed to be used sublingually to improve bioavailability.
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The stated elimination half-life is also consistent with the duration of the subjective effects-- if I use melatonin to fall asleep and then get distracted from sleeping for more than about an hour or two, soporific effects expire. I don't remember if I still oversleep, though.
End of conversation
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Does zilch for me
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Is bioinformatics your job?
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I wanted to switch Zolpidem to Melatonin, but I will not even consider it
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I tried this same experiment on myself a few years ago (taking megadoses) and found it to be worthless even then.
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