Pretty convincing results about previous polygenic height papers mistaking genetic stratification for polygenic selection signal. https://www.biorxiv.org/content/early/2018/06/28/355057 … #genomicspic.twitter.com/DYjYI5W7Kw
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But that doesn't explain the positive sibling results...https://twitter.com/gwern/status/1011269203205197827 …
My guess is that it can biased even the sibling based GWAS because these rely on the LD patterns to get the association with the causal variants and hence the trait of interest. Thus, if one trains on mixed-Euro siblings, one is indirectly using the LD patterns for association.