n=48 for non-human primate studies is HUGE.
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Yup, I would be satisfied w/ those numbers even in a mouse study. And there are 3 independent experiments showing essentially the same result in different modalities. Plus sample size for controls usually doesn't need be as big because background mortality well known & low.pic.twitter.com/cNQDx6MmdQ
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E.g. in figure (e) one doesn't need a big control sample to know 100% gestational mortality indicates an effect. Anyway my feeling w/ experiments like this is people worry too much about P values, which is the easy part, the hard part is replicating the result in other labs/"IRL"
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Well actually, I should correct what I said: the controls aren't untreated, clearly. But this works in favour of the study, even better control than untreated, and in terms of main effect the ZIKV infections are still compared w/ background knowledge about mortality.
End of conversation
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