Humans apparently have ~100 genes that can be deleted without noticeable consequence!? That's 0.5% of our 20k genes. https://www.nature.com/articles/nrg3871 …pic.twitter.com/bU5O0LeOTL
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Not too surprising. Look at all the minimal genome work in yeast and bacteria: there are a lot of different minimal subsets all of which still yield a living organism, since different combinations can cover for various absences.
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Fwiw the study doesn't seem to show you can just delete those regions as an intervention with no consequence, no?
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No, CNVs can be harmful, but by collecting from 'healthy' individuals (scare quotes because we're all sick and unhealthy compared to what we could be), it does imply that many CNVs do little. Consistent with the modest CNV GWASes for traits so far too as well.
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1/Thanks! I likely fail to comprehend something basic. My point was that, since they collected from "healthy" people of different pops., the functionality of the missing/useless CNV might be realized elsewhere for people in that pop - i.e., it's not the same as an intervention to
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Well, there's only so many genes. If you can find deletions in healthy living people for X% of known genes, then at worst, assuming all other deletions are fatal, only 100-X% of genes are inherently necessary. Looking for the dog that didn't bark like ExAC.
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This is not true. The B. subtilis and E. coli minimal genome projects have shown that >90% of their genes are non-essential. There is very little non-coding DNA to delete in the first place. Same for yeast.
Thanks. Twitter will use this to make your timeline better. UndoUndo
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