EA3 polygenics at 16% R2 now, or r = .40. Great progress being made. I expect r = .50 before year's end. https://twitter.com/kph3k/status/1009875245900156928 …pic.twitter.com/VQQP02q73S
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Predictive validity of PGS scales with Fst to training population (look up animal breeding studies). Ancient genomes often have quite small Fst to modern Europeans, so validity is expected.
the scientific standard for proving causation is 1) preceding in time, and 2) same effect in every population. So the extent to which a PGS has predictive validity in every country is the extent to which the genomic variants are proven to cause IQ, instead of just correlating
but the more important question is WHY does accuracy decrease with Fst? because other races have different genetic architecture or because the same genes that increase IQ in America may decrease it in Asia (reaction norms).
what about neanderthal genomes? i expect they have HUGE Fst to all modern humans
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