Human genomics is so backward. Breeders wrote a big review of polygenic score selection in 2001. Here's an an advanced version of breeder's equation. http://gen.lib.rus.ec/book/index.php?md5=DA3E3E1328F067CE1E77FC0DACE3809B …pic.twitter.com/5aBLGG3KbN
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As far as I can see, the idea goes back to at least 2009 at MIRI. https://web.archive.org/web/20091214014113/http://theuncertainfuture.com/faq.html#7 …
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The way human genomics is done today owes a lot to agricultural breeding. Peter Visscher, for example, did his PhD on animal breeding and only became a human geneticist later.
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