My initial reaction to this is extreme scepticism, but intriguing! https://www.nature.com/articles/s41559-017-0446-6 …https://twitter.com/AdrienneLaF/status/953019306840903680 …
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Als antwoord op @pathogenomenick
I share your skepticism - Enterobacteriaceae quite frequent in these types of samples. Here’s a plot I made many years ago from ancient teeth, modern teeth, soil, and some HMP populations. Will need to find my old files and look closer tomorrow.pic.twitter.com/oJyv6WHql9
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Als antwoord op @K_G_Andersen @pathogenomenick
Sounds a bit similar to this story - http://www.ijidonline.com/article/S1201-9712(06)00053-1/fulltext …
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Vågene and co. (admittedly myself included) provide multiple whole genomes from multiple individuals, with 2 at high coverage.
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Didn’t intend to impugne your work - the plague of Athens paper just used PCR to amplify short fragments but then misinterpreted the relatedness to typhoid.
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I read this multiple times and did some secondary (meta) analyses - my skepticism has turned to enthusiasm. I think it's an interesting study, with well-supported conclusions (in the article - NOT the news!).
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Yes. Good also that the data shows evidence of DNA damage. Not likely modern free living.
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Agreed, although that *could* have come later (e.g. you see DNA damage in soil bacteria from ancient teeth too). I did not look too closely at their phylogenetic claims (Fig. 3), the description of which had me a little puzzled...
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There are two questions. 1. Is it ancient? (Sounds like yes) 2. Is it truly the cause of this plague? (Jury very much out)
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To 1. I'd add "did the bug infect these individuals" > yes. To 2. - definitely agree, however, enterica is not an unreasonable candidate (which is what the authors say - they don't say "it's definitely S. enterica". Plus, no enterica in pre-epi samples.
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