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Strengths: 1. They look at samples pre- and during-epidemic. 2. They clearly find S. enterica in epidemic samples. 3. Unlike most news coverage, the authors are careful with their conclusions. 4. They themselves acknowledge there is much more to be done.
Weaknesses: 1. They don't (can't) look at RNA. This is a major problem, because RNA viruses are more likely suspects (and viral hemorrhagic fever has previously been hypothesized). 2. Could S. enterica really cause an epidemic with this size and severity? Maybe..
But what about pathology inconsistencies? (I’m personally a staunch arenavirus hypothesis supporter.)
Agreed - tried to imply that with my 'weaknesses'. The authors handle that (to an extend) in their discussion. The major issue here is no RNA - that's a biggie, since that's the only way to get the arenas or other VHFs.
Anecdote: young & healthy friend was hospitalised & on IV fluids in Mexico with salmonella in November. In the past, if undernourished & without care, outcome could easily have been fatal despite youth...
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