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Having read this article multiple times and performed secondary analyses, I think this is an interesting study with well-supported conclusions about the mysterious Cocoliztli epidemic. Very cool!https://www.nature.com/articles/s41559-017-0446-6 …
Strengths: 1. They look at samples pre- and during-epidemic. 2. They clearly find S. enterica in epidemic samples. 3. Unlike most news coverage, the authors are careful with their conclusions. 4. They themselves acknowledge there is much more to be done.
Weaknesses: 1. They don't (can't) look at RNA. This is a major problem, because RNA viruses are more likely suspects (and viral hemorrhagic fever has previously been hypothesized). 2. Could S. enterica really cause an epidemic with this size and severity? Maybe..
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