To be honest, not the best or promising pipeline - targets limited and easy resistance mechanismshttps://twitter.com/LassaFeverNews/status/753178479860953088 …
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Als antwoord op @_b_meyer
@LassaFeverNews It does cost $2,000 to get a copy, however!2 antwoorden 0 retweets 0 vind-ik-leuks -
Als antwoord op @K_G_Andersen @LassaFeverNews
1/n bottom line, after around 600k screened compounds, there are ca 15 compounds, majority targeting GPC
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2/n all of which target GP2-SSP interaction - resistance by 1-2 point mutations, others are nucleoside analogs
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3/3 which only work early in infection, resistance not tested yet
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I hope to finish a screen in a month or so looking at a specific (different) target and have another
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identified binding pocket, that would make a great target, where the virus is replicative dead - need to sit
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down with a great chemist for this though
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That's good news! Definitely need better options!!
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Als antwoord op @K_G_Andersen @LassaFeverNews
Fingers crossed!!
0 antwoorden 0 retweets 0 vind-ik-leuksBedankt, Twitter gebruikt dit om je tijdlijn te verbeteren. Ongedaan makenOngedaan maken
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