"we see no clear evidence of selection for stronger ACE2 binding, consistent with SARS-CoV-2 already possessing adequate ACE2 affinity at the beginning of the pandemic"https://www.biorxiv.org/content/10.1101/2020.06.17.157982v1 …
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Can you point out similar (RNA) viruses that do not have strong positive selection in their external proteins, and signs of purifying selection within weeks of emergence in humans? Agreed- we think pre-circulation in humans is possible as well and should be investigated.
Answering that question would require a broad formal analysis across multiple viruses, which I haven't done. Ebola (early) I have looked at previously, and there we get a dN/dS of ~0.5, while SARS2 (early) is ~0.3 and SARS1 (early) ~1.8.
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Thank you. We can take a look at the Ebola genomes to see if it's a fair comparison. We are mainly waiting on the new mink<>human SARS2 isolates from the NL to do dN/dS and sitewise modeling. The authors said that they may release some of those genomes after a few weeks.
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They already released some of the mink genomes on GISAID - they have dN/dS ~0.9. Would need more data to get better estimates though.
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Comparison of multiple viruses was what I really wanted to do initially! Just not sure which viruses to work on. I think it may be a more interesting contribution to the field in the long run.
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