"we see no clear evidence of selection for stronger ACE2 binding, consistent with SARS-CoV-2 already possessing adequate ACE2 affinity at the beginning of the pandemic"https://www.biorxiv.org/content/10.1101/2020.06.17.157982v1 …
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I think there are 2 issues: (1) Regarding the pangolin CoV - there is only the -1- pangolin CoV with a highly similar RBD to SARS2. It also remains a mystery how that single batch of pangolins contracted this CoV, possibly during smuggling when exposed to other animals & humans.
These are not issues. Two independent groups have found the same pangolin CoV (one buried in the SRA) and we are so undersampled that we can't possibly expect to capture every single evolutionary step. There are many unknowns when it comes to SARS2, but this one is solved.
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We have a manuscript under editorial consideration on the pangolin CoVs published by the 2 groups (which are not independent). The CoVs are so identical (99.95%) that they use the same dataset to construct their genomes. Majority of the RBD sequence hails from a single sample.
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I think it's imperative for the 2 groups to make publicly available the sequencing data that they used to generate their full genome sequence. And for someone to look into the smuggled pangolins from March 2019, Guangdong, before it becomes impossible to trace.
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"Identifying & cataloguing the viruses carried by pangolins is a logical approach to evaluate the range of potential pathogens & help with conservation." The most trafficked mammal on Earth & they go after viruses! No, more like part of a wet market story!https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893680/ …
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Oh. The RBD doesn’t bind. The samples were from 1% to 26.4% by mass human. Human 100% full length unique reads all over the SRA. as the GD S1 is different—even that still infects humans 2x+ better than pangolins. This did not evolve in a pangolin at all.pic.twitter.com/Oms2FqgtJC
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