"we see no clear evidence of selection for stronger ACE2 binding, consistent with SARS-CoV-2 already possessing adequate ACE2 affinity at the beginning of the pandemic"https://www.biorxiv.org/content/10.1101/2020.06.17.157982v1 …
-
Do you mean that it is unsurprising because this RBD (97% identity between GD pangolin CoV and SARS2) already exists in nature?
Yes - the RBD from SARS-CoV-2 clearly exists in nature as we have now seen it from a couple of pangolin CoVs. That means that the RBD from SARS2 is so "well adapted" to human ACE2 binding because of evolution in some (unknown) animal reservoir / intermediate host.
-
-
I think there are 2 issues: (1) Regarding the pangolin CoV - there is only the -1- pangolin CoV with a highly similar RBD to SARS2. It also remains a mystery how that single batch of pangolins contracted this CoV, possibly during smuggling when exposed to other animals & humans.
-
(2) Although a 97% identical RBD exists in another CoV, this doesn't explain the purifying selection and genetic stability of the circulating SARS2 RBD as early as Dec 2019.
- Nog 7 antwoorden
Nieuw gesprek -
-
-
Care to explain the anomalous nature of those pangolin CoV strain?https://twitter.com/TheSeeker268/status/1272041683404730373?s=20 …
-
I read this paper, which raises impt points. It's ultimately difficult to know what is happening when scientists cannot independently reconstruct the Guangdong pangolin CoV genome. Is there human contamination? Does the genome reflect multiple viruses (from multiple hosts)?
- Nog 1 antwoord
Nieuw gesprek -
-
-
Deze Tweet is niet beschikbaar.
-
Deze Tweet is niet beschikbaar.
- Nog 2 antwoorden
-
-
-
The Goldilocks of RBD. Not quite too pangolin, not quite too RaTG13, but just right for humans. It’s all that zoonotic transfer between salmon that makes it so perfect.
-
Poor salmons. Scapegoats. ]=
Einde van gesprek
Nieuw gesprek -
-
-
Bedankt, Twitter gebruikt dit om je tijdlijn te verbeteren. Ongedaan makenOngedaan maken
-
Het laden lijkt wat langer te duren.
Twitter is mogelijk overbelast of ondervindt een tijdelijke onderbreking. Probeer het opnieuw of bekijk de Twitter-status voor meer informatie.