"we see no clear evidence of selection for stronger ACE2 binding, consistent with SARS-CoV-2 already possessing adequate ACE2 affinity at the beginning of the pandemic"https://www.biorxiv.org/content/10.1101/2020.06.17.157982v1 …
Yes, but there's no mystery here: "Within the newly described SARS-CoV-2 clade, GD-Pangolin binds ACE2 with slightly higher affinity than SARS-CoV-2 [...]"
-
-
Do you mean that it is unsurprising because this RBD (97% identity between GD pangolin CoV and SARS2) already exists in nature?
-
Yes - the RBD from SARS-CoV-2 clearly exists in nature as we have now seen it from a couple of pangolin CoVs. That means that the RBD from SARS2 is so "well adapted" to human ACE2 binding because of evolution in some (unknown) animal reservoir / intermediate host.
- Nog 9 antwoorden
Nieuw gesprek -
Het laden lijkt wat langer te duren.
Twitter is mogelijk overbelast of ondervindt een tijdelijke onderbreking. Probeer het opnieuw of bekijk de Twitter-status voor meer informatie.