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This needs repeating. Dex (like other corticosteroids) is immunosuppressive, so taking this prior to exposure or during mild disease would be detrimental and likely significantly increase risk.https://twitter.com/kakape/status/1273278171048218627 …
In plain language, what I am trying to say here is this - please don't try to take this to protect yourself against COVID-19 (a prophylactic). It will *increase* your chance of infection and disease, not decrease it.
Looking at the numbers from the RECOVERY trial yesterday, there's a hint of exactly this effect in the data - the rate ratio is 1.22 [0.86 - 1.75] for mild disease* (so increased risk of death) vs 0.65 [0.48 - 0.88] for vented patients (so decreased risk of death).
*Note - this difference isn't statistically significant (I think - it's unclear to me exactly what test was used for their p=0.14).
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