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Thanks Natalie! One quick additional comment on immunological 'dark matter' (also goes for 'genetic resistance'). If we indeed had a lot of 'dark matter', we wouldn't expect super spreading events to have such high attack rates (~80-90%).
To me, the fact that the attack rates are so high during these events is really the best evidence to show that almost all of us are susceptible - sure, there might be some 'dark matter', but if it exists, it's very low.
I completely agree. Are there any papers or has anyone compiled info on these super-spreading event? I think a formal analysis across geographies and age-groups would be very informative.
Totally agree, but I haven't come across any yet - hopefully we might see some in the near future. Would be very helpful.
What I think we don't know is how "dark matter" might play a role in development of severe disease. I can hand-wave about that possibility, but really not convinced of much including whether it's a real phenomenon.
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