This is a nice read - but note, n=1 (out of n=45). One thing I found interesting that the article didn't explain in detail, is the fact that the subject appeared to develop a severe allergic reaction to the booster. https://www.statnews.com/2020/05/26/moderna-vaccine-candidate-trial-participant-severe-reaction/ … 1/
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Deze collectie tonen
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That reaction could likely have been against the vaccine backbone (mRNA) or the immunogen expressed (SARS-CoV-2 spike protein). However, the reaction took several hours to develop, so presumably this would likely be against the spike protein? (which takes time to express) 2/
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This is a small early study and the subject was in the 'high dose' group, but if the vaccine can lead to sensitization in the first shot, followed by a severe allergic reaction in response to the booster, then that needs very careful investigation. 3/
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Combine this read with this really great reporting from Helen Branswell on some of the challenges getting a
#COVID19 vaccine (fast). We'll get there, and I'm optimistic we can get one leading to sterilizing immunity, but it'll likely take (some) time. https://www.statnews.com/2020/05/22/the-world-needs-covid-19-vaccines-it-may-also-be-overestimating-their-power/ … 4/3 antwoorden 4 retweets 19 vind-ik-leuksDeze collectie tonen -
Als antwoord op @K_G_Andersen
I’m curious why you’re optimistic about sterilizing immunity (though i don’t love the term). I’ve been optimistic as well, but a lot of cold water thrown the last couple weeks and I’m struggling to articulate the optimism.
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Als antwoord op @stgoldst
Let me clarify - I *chose* to be optimistic
. Many compare SARS-2 immunity to common cold bCoVs, but I don't think we can do that-very different infections. For SARS and MERS we don't understand immunity, but I haven't heard of a SARS reinfection and SARS-2, much more like that2 antwoorden 0 retweets 2 vind-ik-leuks -
Als antwoord op @K_G_Andersen @stgoldst
Neutralizing antibodies to SARS and MERS will decline after a couple/few years so lasts much longer than CC CoVs - not lifelong, mind you, but longer. Do those nAbs lead to sterilizing immunity? Dunno, but not unreasonable to think. So I go with that until proven otherwise
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Als antwoord op @K_G_Andersen
I’m with you. Plus nAbs titers aside, memory B cells+T cells, I think there’s immunity there. Entirely sterilizing I don’t know, but I’d be very very surprised if there was no protection.
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Yup, there's definitely immunity there, no question - only we don't know for how long and whether sterilizing or not. T-cells might also be more important than we realize (both in modulating disease severity and immunity).
We'll know in a couple of years
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Als antwoord op @K_G_Andersen
Ha, we will! We’ll certainly have the statistical power to make some good conclusions.
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