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This is a small early study and the subject was in the 'high dose' group, but if the vaccine can lead to sensitization in the first shot, followed by a severe allergic reaction in response to the booster, then that needs very careful investigation. 3/
Combine this read with this really great reporting from Helen Branswell on some of the challenges getting a #COVID19 vaccine (fast). We'll get there, and I'm optimistic we can get one leading to sterilizing immunity, but it'll likely take (some) time.
https://www.statnews.com/2020/05/22/the-world-needs-covid-19-vaccines-it-may-also-be-overestimating-their-power/ …
4/
I’m curious why you’re optimistic about sterilizing immunity (though i don’t love the term). I’ve been optimistic as well, but a lot of cold water thrown the last couple weeks and I’m struggling to articulate the optimism.
Let me clarify - I *chose* to be optimistic 
. Many compare SARS-2 immunity to common cold bCoVs, but I don't think we can do that-very different infections. For SARS and MERS we don't understand immunity, but I haven't heard of a SARS reinfection and SARS-2, much more like that
No evidence reaction was allergic. Immune-mediated vaccine reaction, the type one would expect.
Thanks Matthew for weighing in. His first reaction sounds like that, but the reaction to the booster seems like it could have been an allergic reaction to the first shot. I'm not sure this is necessarily what we would/should expect?
We should start building state-wide plans now on the distribution of vaccines when they do come about. Who will get them first? How will distribution work effectively so every corner of America can get what they need?
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