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That reaction could likely have been against the vaccine backbone (mRNA) or the immunogen expressed (SARS-CoV-2 spike protein). However, the reaction took several hours to develop, so presumably this would likely be against the spike protein? (which takes time to express) 2/
This is a small early study and the subject was in the 'high dose' group, but if the vaccine can lead to sensitization in the first shot, followed by a severe allergic reaction in response to the booster, then that needs very careful investigation. 3/
Combine this read with this really great reporting from Helen Branswell on some of the challenges getting a #COVID19 vaccine (fast). We'll get there, and I'm optimistic we can get one leading to sterilizing immunity, but it'll likely take (some) time.
https://www.statnews.com/2020/05/22/the-world-needs-covid-19-vaccines-it-may-also-be-overestimating-their-power/ …
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