#Epitwitter and others @trvrb @K_G_Andersen @ChristoPhraser is there any evidence yet to support (or refute) existence of genetic differences in transmissibility or case-severity in SARS-CoV-2?
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Glad to be a witness to this exchange, too.
There's too little good metadata to make any good conclusions thus far, but based on current data, there's nothing to suggest there are any differences (same as prior). D614G as Nate mentioned, might have a skew towards slightly lower Ct (<1/2 log) [...] 1/2
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and may also be slightly skewed towards higher proportion of younger people, so CFR estimates would have to be age-stratified (but I don't think we'll see a diff). The "it transmits better" hypothesis I don't buy-it's likely due to founder. R0 also appear same for D614 and G614.
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