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One key extra question - I have been looking at papers investigating longevity of antibody responses to SARS-CoV (not HCoV-19) in human survivors and it appears IgGs start rapidly declining after ~ 2 years. Are there better studies? Do we know longevity of cellular immunity?
... and since I forgot to mention this last night - we obviously want to get herd immunity in the population, but via a vaccine. The ‘test and trace’ strategy will buy us time to get to that stage (likely a 3-5 year timeline).
Is there any reason immunity would last longer with a vaccine? Or would the idea just be to use boosters then to extend immunity past 2 years?
No, unfortunately not - typically natural infection leads to longer-lasting immunity than a vaccine. If immunity is hard to obtain, it will likely be harder to make a vaccine also - however, with a vaccine we can boost, so you can imagine having a vaccine we could give every year
If it becomes endemic, there could be some immune boosting from regular exposure that wouldn’t have happened with SARS though, as it disappeared. Might result in slower waning.
vaccines ? safe? viral ADE, viral superinfection? Rates of mutation,countries willfully ignoring directive to “break chains of transmission” contain,leading to large intra- community transmissions numbers., hence more mutations. all lowers the likelihood of safe vaccine.
Antibody halflife - especially IgG might not be the best measurement of immunity. I do not remember fulminant disease of other Corona viruses- thus cellular immunity must be encountered. It is all about protecting the healthcare system while building immunity.
I think the point is that Corona is here and will not disappear, so either we isolate ourselves for several months more (3-5) and wait for the second wave, or we slowly try to start our lives with Corona still around. Immunity would be a welcome bonus.
Is it likely that immunity from a vaccine will last longer than natural immunity?
3-5 years to a vaccine ? Most often 18 months is quoted.
Præcis. Vaccine er vejen frem. Den eneste menneskelige måde at opnå flokimmunitet på
I am not an expert at all, could you clarify: how the vaccine would ensure a longer coverage than 2yrs? Considering IgG go down after 2yrs .. as you said
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- are talking about slowly building herd immunity against 
