Sampled viruses differ from the original Wuhan outbreak virus by only 0 to ~20 mutations. Almost all of these mutations will do very little to affect viral function. 6/13pic.twitter.com/FdzSfIXST9
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This brings us to the other overloaded definition of strain: a functionally distinct virus genotype. 7/13
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What's very tricky is that we can't know without doing experiments if one genetic variant behaves differently than another, especially when there's only a small handful of genetic changes between them. 8/13
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Mutations can occur that change the proteins made by the virus and other mutations can occur that change the genome but not the proteins. This is due to the degeneracy of the genetic code (https://en.wikipedia.org/wiki/Genetic_code#Degeneracy …). 9/13
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There have been only 11 mutations to proteins that are widely distributed. These are *potentially* functionally distinct variants that deserve attention and experimental and clinical follow up. But my expectation would be most have "little effect" without further data. 10/13pic.twitter.com/YRnCSdmFFf
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Finally to the initial question at the top of the thread, in terms of immunity, there is a single widely circulating mutation in spike protein (D614G). Spike is present on the surface of the virus and is what the immune system sees. 11/13pic.twitter.com/S9kvlLjrsu
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My expectations from influenza, norovirus and other antigenically variable viruses is that a single mutation outside the receptor binding site is unlikely to have much of an effect on immunity. 12/13
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However, this could be studied via cross-neutralization assays to see if sera from recovered individuals respond differently to these two variants. These assays are routinely used in influenza vaccine strain selection for exactly this purpose. 13/13
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Als antwoord op @trvrb
So strange - no idea where they came up with that title or the idea of 8 'strains'. If you read the quotes it's all about "it's basically all the same", "don't overinterpret the trees", "careful how you interpret the data", etc. So bizarre.
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Als antwoord op @K_G_Andersen @trvrb
Weird. It’s almost as if they deliberately wrote the headline to get people to click on the article or something.
1 antwoord 0 retweets 12 vind-ik-leuks
Als antwoord op @EvolveDotZoo @trvrb
News outlets do that? Weird.
07:42 - 31 mrt. 2020
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