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RDTs could instead be made to work with sputum or nasal aspirates, but those fluids can be hard to handle compared to blood, which is typically quite 'clean'. That said, I'm quite sure we'll see those tests pop up, only it'll take time. 6/n
In summary: RDTs = measure pathogen antigens (by having antigen-specific IgGs on the test itself). Serology tests = measure antibodies (IgM and/or IgG) to pathogen antigens (by having pathogen-derived antigens (proteins) on the test itself). 7/n
Both of these tests are great and critical, but they serve different purposes - RDTs for diagnostics; Serology tests for understanding previous exposures (e.g., in populations, healthcare workers, etc.) - these can give us estimates of the real number of infected people. 8/n
One comment specific to IgM - these *can* at times be used to diagnose patients that are late in their disease course. This can happen if somebody has had symptoms for quite some time, but no PCR-based diagnostic taken. 9/n
We recorded a video of how the Coronavirus IgG/IgM antibody blood test works. False negative rate is high as Coronavirus antibodies only show up in the blood after 7 days (if at all)https://twitter.com/onggunhao/status/1244215820491751425?s=19 …
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