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In partial response to the proposed "S" and "L" #coronavirus strains, @MaryPetrone10 and I wrote this op-ed for @cnnhealth.
Our primary goal was to educate the public on why we shouldn't fret about virus mutations during the epidemic.https://www.cnn.com/2020/03/07/health/coronavirus-mutations-analysis/index.html …
Good stuff. One minor comment - coronaviruses actually *do* have proof reading activity. A rarity in RNA viruses, but this one has it (so presumably the mutation rate is lower - however, the substitution rate remains the same and is the one that matters).
Correct. In SARS the mutation rate is about 2x10^-5, you mutate ExoN (the proof reading part), you'll end up with 3.3x10^-4
Why wouldn't proofreading activity lower the substitution rate?
Because their genomes are respectively larger, so the substitution rate / genome stays similar to other RNA viruses.
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