Viruses acquire mutations every single time their genome is copied. Treat this with *extreme* caution. Almost all mutations are meaningless.https://twitter.com/Dawn_Kopecki/status/1235225831296950274 …
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Nope, if able to link the phenotype or clinic data, mutations are meaniful. The rapid mutation of virus is not for *meaningless* - it is designed by nature for fitness and survival. The critisim of that paper is sampling bias and sparsity of data but not 'meaningless' of mutation
"Almost all mutations are meaningless". "Almost all". That's the key point from Stephen here - doesn't mean that all are meaningless, it just means that most of them are.
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Yes, what Kristian said. Even for presumptively impactful mutations, linking a given mutation to real-world phenotypic changes is extraordinarily difficult. The odds of a mutation arising that meaningfully impacts global transmission? Low, I expect.
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Just back from group meeting with Prof. Peter Satir and learned all cilia in eucaryote might be eloved from virus entry. If able to link phenotype, the nonimpactful variants are meaniful in a way to inform what are the impactful variants. Might also need to combine bench data.
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