Y'all got examples of virus mutations that may have impacted an outbreak (or were perceived to be)? I'm well versed in mosquito-borne viruses (and know of the ebola one), but struggling outside of that realm. Especially examples in influenza, which i don't know as much about.
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Als antwoord op @NathanGrubaugh
Depends on how stringent your criteria are. There are glycosylation changes (egg adaptations)in flu that affect vaccine protection
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Als antwoord op @_b_meyer
thinking more of that arose during an outbreak. trying to get an idea of epi potential for an individual mutation. I think that we mostly over-react to these events, but would be best to get a more comprehensive view first. Thanks!
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Als antwoord op @NathanGrubaugh
SARS. Lots of good examples from that virus (that I didn’t previously know about). And obviously HIV
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Als antwoord op @K_G_Andersen
Diving into SARS now, which are great examples of mutations/indels that arise during an outbreak, but so far I'm not really convinced that any of these had a bonafide impact on transmission. reading more
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Als antwoord op @NathanGrubaugh @K_G_Andersen
I assume this might be something for you to look at to follow some non-synonymous mutations: http://cov-glue.cvr.gla.ac.uk/#/replacement
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Thanks for sharing - yes, very nifty!
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