A reference: when we sequenced Ebola in 2014 from W. Africa it took us ~ two months from first case to first deposited virus genome. This was with a known virus, in a place we had worked in for 10+ yrs, with full capacity, we knew how to sequence, and worked 100+ hour weeks.
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The resultant paper was published 6 weeks later (and not on bioRxiv - this has since changed):https://science.sciencemag.org/content/345/6202/1369.long …
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For us laypeople, how does this compare? Does this mean scientists in China are able & well trained? Or do all laboratories work at this speed?
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I can't think of any other place that currently would have the capability to do this much in so little time. This is unprecedented IMO and very impressive work by the Chinese scientists.
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It seems to me 96% similarity to this newly recovered bat virus sequence makes these two quite close to being the same virus, no?
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No clue. The alignment in Fig 1c and the tree in Fig 1d are really interesting. When do you call two virus genomes "the same virus" ? A strict % seq identity cutoff seems arbitrary.
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Does the extremely high phylogenetic similarity to BatCoV RaTG13 say definitively this is the virus that spilled over? Or are there many viruses just as similar that could be the source?
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nCoV-2019 is (slightly) different to the one they sequenced in bats, so it's not exactly the same - however, it does point strongly to bats being the reservoir for nCoV-2019 as well.
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1. This is a remarkable achievement, possible because... 2. This new virus is essentially SARS, and will probably be renamed as such.
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I would not call this virus essentially SARS. 79.5% is somewhat close but not nearly the closest relative. They are fairly distinct for being within the same genus.
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