Several more genomes (n=19) have been released and this picture still holds true with a plausible (note, *lots* of caveats) median date of ~ early/mid-December.https://twitter.com/K_G_Andersen/status/1219280708188827649 …
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Als antwoord op @K_G_Andersen
This suggests little diversity in founding viruses: - Either a single animal infected many people, - Multiple animals with similar viruses caused the initial infections, - Or there was only very few crossovers which then spread through person to person transmission.
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Als antwoord op @joel_c_miller @K_G_Andersen
To me the lack of diversity strongly implies that this is primarily person-person transmission.
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Als antwoord op @joel_c_miller
Yes, there's very little diversity in the population (~1 SNP / genome). We can't really distinguish small animal founder population infecting humans vs human-to-human - no SNPs are currently transmitted and we have a star topology.
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Als antwoord op @K_G_Andersen @joel_c_miller
It's clear from the epi data that human-to-human transmission does occur, however, we don't yet know how prevalent it is. Could be all cases (but 1) are H2H, could be a small subset. What we *can* conclude, is that people aren't being infected from a widespread animal reservoir.
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Als antwoord op @K_G_Andersen @joel_c_miller
All things considered, I'm leaning towards human-to-human transmission being the main mode (possibly exclusively by now), but more data is definitely needed.
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Als antwoord op @K_G_Andersen
I agree. For me this lack of diversity is one of the stronger pieces of evidence that it's primarily human-to-human. I have a hard time imagining a scenario having introductions over a longish time period that all come from incredibly closely related infections in animals.
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Agreed, although not entirely impossible - e.g., small animal population recently infected is brought into the food market and then infects people (probably not completely unlikely something like that could happen). But combined with the epi data, H2H seems more plausible.
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