Troubling case of a woman who may have been reinfected with #Ebola triggers review of safety rules around using survivors to help care for cases.
I would wonder if her first infection was a false positive.https://www.reuters.com/article/us-health-ebola-congo-immunity-exclusive/exclusive-who-congo-eye-tighter-rules-for-ebola-care-over-immunity-concerns-idUSKBN1XA0RC …
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Which reference for "lot of" false positive GeneXpert assays during the West Africa 2014-2016 epidemic? Some other PCR assays did actually not perform as well as merely analytical evaluations suggested.
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Local knowledge. The studies you see assess best-case-scenario analytical specificity and don't really give an accurate account of what is really going on during a chaotic situation. I should say, that I think all three options are definitely possibilities here.
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Also, false positives can come about by sample mix ups and record keeping failures, not just from the lab work.
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Apart from mixing up samples or records? Real false positives from GeneXpert should be extremely rare. Specificity of 99.5% in a field study in West Africa: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001980 …. Cartridges for automatic sample processing also help avoiding cross-contamination.
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