We have done a sort of blog post/tutorial on local molecular clocks to look at an interesting latency phenomenon in Ebola virus in non-human hosts. This is work in progress based on genomes published recently by DRC/INRB from current and recent outbreaks. http://beast.community/ebov_local_clocks.html …
Yup, I think that's totally reasonable. I *do* wonder about the potential for an intermediary (amplifying? 'adapting'?) host too though - e.g., great apes. Could the virus create latency in bats more generally, but then bounce between species (prior to outbreaks?).
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Were you able to specifically look at clocks within the current outbreak? I'm not sure data is available, but would be nice to see that the virus did indeed switch from latency (very slow rate) to a 'normal' EBOV rate (e.g., similar to rate estimated for MAKV during outbreak)
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I don’t think it works like that. I think most of the time (in bats, humans whatever) it is replicating and transmitting normally. Many recovered hosts may have latent virus but most never establish another replicating lineage.
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