Justus

@JustusKebschull

Vrijeme pridruživanja: travanj 2018.

Medijski sadržaj

  1. 25. sij

    Intriguingly, the connection to lateral habenula is potentiated both when tone and footshock are paired or unpaired.

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  2. 25. sij

    Similarly, SYNPLA works on ex vivo slices of defense conditioned animals. When expressing myc-NRXN in auditory cortex and/or medial geniculate nucleus, we show that paired tone and footshock potentiate the connection to the lateral amygdala relative to controls.

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  3. 25. sij

    In the paper, we show that SYNPLA works in cultured neurons and hippocampal slice cultures. There we detect a much larger number of SYNPLA signals after chemically induced LTP than in control conditions or when LTP is blocked.

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  4. 25. sij

    In SYNPLA we probe for endogenous GluA1 and the pathway-specifically expressed pre-synaptic myc-NRXN. We only get a SYNPLA signal if a synapse contains both GluA1 and myc-NRXN . Extra-synaptic GluA1 is too far away from the presynaptic partner to make a signal!

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  5. 25. sij

    We do this by PLA. PLA is essentially a double antibody stain that results in a 1000x amplified signal only if the two proteins probed for are closer than 40nm to each other. This happens across the synaptic cleft.

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  6. 21. lis 2019.

    Are you mapping brain circuits by clearing and light sheet imaging, but have a hard time truely quantifying axonal projections? Check out Drew Friedmann's TrailMap (Luo Lab) now on biorxiv. Then you too can make awesome movies like this one!

  7. 20. ruj 2018.

    Want connectivity maps of your favourite model system? We used barcoding and DNA sequencing to map the mesoscale cortical connectome of individual mice in just single experiments. Work impossible without Longwen Huang and . Feedback welcome!

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