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Prikvačeni tweet
Happy to confirm that this is NOT fake news! Very excited to start my own lab
@JHUBME in Oct 2020. Will work on comparative connectomics and barcodes in the cerebellum and beyond! Would never have happended without my mentors@TonyZador and Liqun Luo.Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Intriguingly, the connection to lateral habenula is potentiated both when tone and footshock are paired or unpaired.pic.twitter.com/BktT2SdOB1
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Similarly, SYNPLA works on ex vivo slices of defense conditioned animals. When expressing myc-NRXN in auditory cortex and/or medial geniculate nucleus, we show that paired tone and footshock potentiate the connection to the lateral amygdala relative to controls.pic.twitter.com/3zHp4X1NZx
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In the paper, we show that SYNPLA works in cultured neurons and hippocampal slice cultures. There we detect a much larger number of SYNPLA signals after chemically induced LTP than in control conditions or when LTP is blocked.pic.twitter.com/XxxhnijE2B
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In SYNPLA we probe for endogenous GluA1 and the pathway-specifically expressed pre-synaptic myc-NRXN. We only get a SYNPLA signal if a synapse contains both GluA1 and myc-NRXN . Extra-synaptic GluA1 is too far away from the presynaptic partner to make a signal!pic.twitter.com/lipwzUVRvl
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We do this by PLA. PLA is essentially a double antibody stain that results in a 1000x amplified signal only if the two proteins probed for are closer than 40nm to each other. This happens across the synaptic cleft.pic.twitter.com/BMFl674TVS
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Synaptic GluA1, therefore, is a marker for recently potentiated synapses. The trick is to detect this synaptic GluA1 only in genetically or anatomically specified pathways.
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So, what is this paper about? SYNPLA is a method to label synapses in a specific pathway that recently underwent LTP. The principle is simple. We exploit the fact that after LTP GluA1 temporarily moves into the synapse from extra-synaptic pools.
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New paper out in PNAS today. Long-running collaboration between Malinow and
@TonyZador labs brought to fruition by Kim Dore! Check it out. SYNPLA, a method to identify synapses displaying plasticity after learninghttps://www.pnas.org/content/early/2020/01/22/1919911117 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Justus proslijedio/la je Tweet
Cell-type- and temporally-resolved cell-surface proteomics in intact brains
@CellCellPress. Collab. of Liqun's lab, @aliceyting's lab, Steve's team @broadinstitute. Thank you all! @Stanford@HHMINEWShttps://www.cell.com/cell/fulltext/S0092-8674(19)31391-1 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Justus proslijedio/la je Tweet
Ho ho ho, merry BARseq.
@JustusKebschullhttps://twitter.com/NIHDirector/status/1209147860081610752 …
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Justus proslijedio/la je Tweet
Thought that frontal cortex is all random mixed selectivity, messy? Think again! Great work by a great team,
@ratcortex@agvaughan@PaulMasset@OttTorbenhttps://twitter.com/gottapatchemall/status/1202330151079407616 …
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Justus proslijedio/la je Tweet
“Neocortex–Cerebellum Circuits for Cognitive Processing”
@TrendsNeuro Review by Mark Wagner & Liqun Luo,@Stanford http://bit.ly/WagnerLuoTINS#Cerebellum#Cortex#Reward#MotorControlpic.twitter.com/p3hL5u9wzm
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Justus proslijedio/la je Tweet
Neuroscience
#LMBPhD opportunities in@MRC_LMB Jing Ren group: Developmental assembly of the serotonin system https://bit.ly/2oPUoOT
Apply NOW Deadline 3 Dec 2019: http://bit.ly/2sNTsc3
#PhDpic.twitter.com/1uUmLoStY5
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Justus proslijedio/la je Tweet
We had been rather proud of our 20 genome assembly project in Heliconius, and now we find that Nick Grishin's group has sequenced ALL 845 NORTH AMERICAN BUTTERFLY SPECIES! Mental!pic.twitter.com/H4PHGIdyVg
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Justus proslijedio/la je Tweet
Excited to present a method for profiling cell-surface proteomes in intact tissues, with cell-type, spatial, and temporal specificities. A collaboration of the Luo lab,
@aliceyting lab, and the proteomics team@broadinstitute. Thank you all!https://twitter.com/biorxiv_neursci/status/1187716528436846593 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Justus proslijedio/la je Tweet
Proximity labeling in pupae & adult fly brain reveals changes in neuronal surface proteome over development. New synaptic wiring candidates IDed and 20 validated by fly KD. Great collab w/Liqun Luo & Carr lab. Congrats co-1st authors
@JiefuBiol & Shuo Han!http://tinyurl.com/y2ep5qdwPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Are you mapping brain circuits by clearing and light sheet imaging, but have a hard time truely quantifying axonal projections? Check out Drew Friedmann's TrailMap (Luo Lab) now on biorxiv. Then you too can make awesome movies like this one!
@_Friedmann_ https://www.biorxiv.org/content/10.1101/812644v1 …pic.twitter.com/NObM9FJSNDHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Justus proslijedio/la je Tweet
BARseq paper finally out! Connectivity of thousands of neurons per brain, with gene expression, at single neuron resolution, using in situ sequencing.
@JustusKebschullhttps://www.sciencedirect.com/science/article/pii/S0092867419310748?dgcid=author …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Liked this whole sequencing projections idea, but want more spatial resolution? BARseq is now published! De novo in situ sequencing of barcodes + single neuron tracing for thousands of cells at a time, now out from the Zador lab.
@TonyZador Read it here:https://tinyurl.com/yxnjc5waHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Justus proslijedio/la je Tweet
Looking for students and postdocs to join my lab
@TheCrick, starting early 2020! Working at the intersection of molecular and systems neuroscience, we’ll study how cell types in visual cortex are wired and contribute to visual perception. Please RT / get in touch if interested!Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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