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We just have to turn our bodies into natural
#antiaging/youth pharmacies/factories! Everything we need to be#foreveryoung is likely already inside of us!pic.twitter.com/VMRdq4AFZ9
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Is
#Oxytocin an upstream regulator of the immune system? «The OSS (oxytocin-secreting system) can promote the development of thymus and bone marrow, perform immune surveillance, strengthen immune defense, and maintain immune homeostasis.»#Antiaging https://www.frontiersin.org/articles/10.3389/fimmu.2016.00693/full …pic.twitter.com/UCn4aqAxYV
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Overview over lifespan extending effects in rodents by CR and various compounds: https://joshmitteldorf.scienceblog.com/2018/04/08/the-mother-of-all-clinical-trials-part-i … Only problem is that Michael Rose has calculated that even a lifetime of CR in humans will extend life by a couple of years at most (basically zero). https://blog.humanos.me/paleo-diet-aging-antagonistic-pleiotropy-michael-rose …pic.twitter.com/xuXyzRrrux
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And according to this article, in a 1981 study
#CoQ10 extended lifespan (at least in some female mice) far more than anything else. https://nutritionreview.org/2018/12/coenzyme-q10-plays-many-roles-as-anti-aging-nutrient …#Antiagingpic.twitter.com/r76iTHLxEX
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It has nothing to do with real
#antiaging.#Rapamycin extends murine lifespan but has limited effects on aging «Our data indicated that the longevity effects of rapamycin are not associated with broad modulation of aging.» https://www.jci.org/articles/view/67674?utm_campaign=cover-page&utm_content=short_url&utm_medium=pdf&utm_source=content …pic.twitter.com/IDd7vtCkKz
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And also
#Benfotiamine (BFT) (an emerging#antiaging supplement that seems to work via multiple mechanisms): https://www.europeanreview.org/wp/wp-content/uploads/3261-3273.pdf …pic.twitter.com/nuYeOGIArX
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Almost everything is likely tissue/context/biostatus dependent & it’s why «broad» pharmacological
#mTOR inhibitors etc never will work for «#antiaging» in humans https://vimeo.com/57717019 https://mobile.twitter.com/MolMetab/status/1219683308784832512 …
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Supraphysiologic Administration of
#GDF11 Induces#Cachexia and#Muscle loss in Part by Upregulating#GDF15: https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30076-7 …pic.twitter.com/x36SBea3uh
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Great question but the whole premise is wrong in the first place. The mTOR
#antiaging hypothesis in humans is basically dead and after this failed trial no one is going waste more money on it (which is probably fortunate.) The future is#Rejuvenation not «managing death/decline».pic.twitter.com/6Xx1vecU3b
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The most interesting properties of
#flavonoids, plant compounds & also «#antioxidants» is their epigenetic properties (that’s only now starting to get elucidated), see for example this recent review: https://academic.oup.com/advances/article/10/6/1012/5491277 …#Anticancer#Epigeneticspic.twitter.com/LKqqj9pvvZ
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Well, that idea just isn’t aligned with reality. Diseased/aged people are *catabolic* (and increasingly so the sicker/older they are) NOT «anabolic» and basically all functions starts to decline very early. https://m.youtube.com/watch?v=sppJywBkKB8 …
#Antiagingpic.twitter.com/pz7bjCF4TK
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Does senescence promote fitness in Caenorhabditis elegans by causing death? (David Gems) https://www.sciencedirect.com/science/article/pii/S1568163718302551 …
#AdaptiveDeath#Evolution#GroupSelectionpic.twitter.com/v9kb8QCmWG
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«The existence of different causal explanations at different stages of the disease: identifying these different explanations, and determining if they are connected or not, will benefit researchers.»
#Anticancer#Antiaging#Causalitypic.twitter.com/xHvXZWg4cR
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"Where a probiotic supplement may boast a few strains and 25 billion live organisms per dose, a modest serve of just 25 grams of
#kimchi could provide the same total microbes across a diverse population which may include over 150 genera."#Microbiome https://www.researchgate.net/profile/Christine_Houghton/publication/336578800_Restoring_Gut_Ecology_Harnessing_the_Inbuilt_Defence_Mechanisms_of_the_Gut_Epithelium/links/5da6d3cb92851caa1ba63a4c/Restoring-Gut-Ecology-Harnessing-the-Inbuilt-Defence-Mechanisms-of-the-Gut-Epithelium.pdf …pic.twitter.com/tlzjlJ4dOZ
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Ok, but be careful and see this:
#Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease https://www.thelancet.com/article/S2352-3964(19)30165-3/fulltext …pic.twitter.com/a9OjpbB54V
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«Similar to the melody from an accordion, the output of
#PI3K signaling is shaped by the integration of multiple input parameters.»#Systemsbiologypic.twitter.com/ZNKyhVUdxc
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#Exercise is probably a far more effective#antiaging tool than#metformin or#rapamycin will ever be (but the question is if Met/Rapa will diminish the benefits of exercise). Antioxidant and Adaptative Response Mediated by#Nrf2 during Physical Exercise https://www.mdpi.com/2076-3921/8/6/196/htm …pic.twitter.com/mlOe0SNkJX
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«In conclusion, dietary fibers can be considered key ancestral compounds that preserve gut ecology, especially regulating macronutrients and host physiology.»
#microbiome#fiber#omega3pic.twitter.com/IoCuR7vGwx
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It’s complex but according to the
#5XFAD mouse model in this paper it seems like the earliest signs of#Abeta may occur in a part of this brain circuit: https://www.frontiersin.org/articles/10.3389/fnana.2019.00017/full … It seems by delivering a designer drug that inhibited neuronal «overactivity» there it reduced Aβpic.twitter.com/XEfyvX0q97
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But might it be
#antiaging? Differential regional decline in dopamine receptor availability across adulthood: Linear and nonlinear effects of age. 2019 https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24585 … https://sites.duke.edu/kseaman/research/aging-and-dopamine …#Dopaminepic.twitter.com/YkOQlDYozz
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